Historic Indian spiritual texts say this tree is ‘One which cures all illnesses and ills.’ Revered in India, it’s additionally known as the ‘reliever of illness,’ in addition to village pharmacy, nature’s drug retailer and divine tree.
In 1992, the US Nationwide Academy of Sciences described it as ‘a tree for fixing international issues,’ and extra just lately the United Nations declared it the ‘tree of the 21st century.’
It’s already been the topic of 4 world conferences and a number of other worldwide packages.
This superb show of curiosity and enthusiasm springs from the plant’s potential to stop and deal with an enormous variety of well being issues, together with most cancers.
It’s referred to as the neem tree.
The historical past of neem (Azadirachta indica) could be traced again to Siddha, an Indian and Sri Lankan medical system, one of many oldest recognized medical traditions. Its origins date again 12,000 years.
And neem is the primary medicinal plant talked about in Siddha. It’s stated to discourage infectious illnesses together with smallpox and to have powers that may chase away evil spirits.
The earliest documentation of the plant, four,500 years in the past, talked about that each a part of neem — bark, root, seed, leaf, flower and fruit — could possibly be used for medicinal functions.
At this time, there are round 18 million neem timber in India, and Indian emigrants took it to different locations on the earth the place they settled. It’s now properly established in at the very least 30 nations, together with small plantations within the US.
Neem timber develop quick — 20 ft in a mere three years. They will develop the place rainfall is restricted, thrive in desert-like warmth as much as 120º F, and reside for 200 years.1
Staggering variety of well being advantages
Greater than 300 compounds have been remoted from neem, together with 140 with medicinal properties.
A brief assessment of neem revealed within the Biojournal of Science and Know-how (BJST) in 2016 summed up the plant’s advantages:
“Numerous elements of this plant … include compounds with confirmed anti-inflammatory, anti-pyretic, anti-histamine, anti-fungal, antibacterial, anti-ulcer, analgesic, anti-arrhythmic, anti-tubercular, anti-malarial, diuretic, spermicide, anti-arthritic, anti-protozoal, insect repellent, anti-feedant, anti-hormonal properties and anti-cancerous makes use of.”2
As I discussed, it appears each a part of the plant provides a well being profit:
Leaves: Extracts and/or pastes for pores and skin cleaning and infections together with pimples, boils, burns, wounds, insect bites and eruptions. Conditioning and strengthening hair, selling hair progress and treating dandruff. Cleaning and soothing the eyes, providing aid from fatigue and irritation. Boosting the immune system, decreasing elevated blood sugar and therapeutic ulcers.
Flowers: Intestinal worms, nausea and anorexia. Can be discovered as an aromatherapy oil for its calming properties.
Twigs: Historically, and even at present, these are chewed to wash the tooth, battle germs within the mouth, heal swollen gums and stop or take away plaque.
Bark: Gastric acid discount, chilly sores, ache aid, and boosting the immune system.
Seeds: A wealthy supply of fatty acids and antioxidants, the seed oil is utilized in soaps, hair, beauty and wonder merchandise, and in mosquito repellents.
Fruit: Oil is extracted from the pulp in addition to the seed and is utilized in an identical means. Tea made out of the fruit is used to maintain the kidneys and prostate wholesome.
Sap: Basic weak spot and pores and skin illness.three
Because the BJST abstract suggests, neem has so many useful properties it might be of worth for nearly all well being considerations. However I’m obliged to say that few human trials have been carried out.
Those that exist present neem acts as a mosquito repellent,four reduces mouth micro organism, plaque and gum illness,5,6 heals abdomen and peptic ulcers,7 is “extremely efficient” towards head lice,eight and improves immunity (CD4 rely) in HIV sufferers.9
Of the various compounds present in neem, the considered one of most curiosity to most cancers sufferers is nimbolide, derived from limonoid, which is said to the terpenoid class of plant chemical compounds.
Nimbolide can scavenge free radicals and possesses antioxidant results larger than vitamin C.
Research utilizing lab-cultured most cancers cells exhibit nimbolide works towards the illness in 5 foremost methods.10
Induces apoptosis (most cancers cell suicide) by way of a variety of mechanisms – -increasing pro-apoptotic proteins, reducing anti-apoptotic proteins, and producing free radicals (reactive oxygen species).(Free radicals have each constructive and damaging results. On this case, they’re working in ways in which profit us).
Reduces angiogenesis by inhibiting VEGF, a progress issue that helps provide new blood vessels for cancers to develop and unfold.
Prevents proliferation by way of cyclin discount and by decreasing an enzyme it relies upon upon. Cyclin is a protein that helps regulate the cell cycle. Cell cycle arrest prevents the expansion of most cancers.
Reduces metastasis by inhibition of MMP 2 and MMP 9. Matrix metallopeptidases are enzymes most cancers cells use to dissolve surrounding collagen and connective tissue to allow them to unfold and invade different organs.
Promotes chemoprevention which helps cease most cancers from creating by inhibiting part 1 carcinogen activation enzymes and inducing part 2 carcinogen cleansing enzymes.
Shrinks most cancers cells by 70-80 %
Though there are not any human research, findings from the lab are very encouraging.
Prostate most cancers: Scientists on the Nationwide College of Singapore carried out a 12-week research of nimbolide given by mouth to mice with prostate most cancers. The tumor shrank by 70 %, and its unfold was suppressed by 50 %.
In line with Affiliate Professor Gautam Sethi, who led the research, “…we’ve got demonstrated that nimbolide can inhibit tumor cell viability — a mobile course of that immediately impacts the power of a cell to proliferate, develop, divide, or restore broken cell elements — and induce programmed cell demise in prostate most cancers cells.”
He continued, “That is potential as a result of a direct goal of nimbolide in prostate most cancers is glutathione reductase, an enzyme which is answerable for sustaining the antioxidant system that regulates the STAT3 gene within the physique.
“The activation of the STAT3 gene has been reported to contribute to prostate tumor progress and metastasis. We now have discovered that nimbolide can considerably inhibit STAT3 activation and thereby abrogate the expansion and metastasis of prostate tumor.”11
Pancreatic most cancers: Scientists at Texas Tech College Well being Sciences Middle El Paso examined the compound on pancreatic most cancers cell strains and in reside mice.
In cell strains, the dimensions and variety of pancreatic most cancers cell colonies have been lowered by 80% and their migration and invasion capabilities have been curbed by 70%. Progress and metastasis was likewise inhibited within the mice. In each tradition and mice, regular cells have been unhurt.
Senior writer Rajkumar Lakshmanaswamy stated, “The promise nimbolide has proven is superb, and the specificity of the remedy in the direction of most cancers cells over regular cells could be very intriguing.
“Nimbolide appears to assault pancreatic most cancers from all angles.”12
As chances are you’ll know, pancreatic most cancers is among the deadliest varieties and the toughest to deal with, so any remedy that helps is welcome and essential.
Oral most cancers: In 2017 a analysis staff led by professor Siddavaram Nagini of Annamalai College in Chidambaram, India, discovered that nimbolide might inhibit oral most cancers in hamsters by concentrating on a tumor suppressor protein referred to as RECK.
The researchers concluded that “nimbolide could also be a strong therapeutic strategy to stop oral most cancers development.”
Commenting on the research prof Nagini stated:
“RECK has tumor-suppressing properties. In regular cells it maintains tissue structure and prevents infiltration and unfold of tumor cells to different organs. In most cancers, an array of molecules inhibits the perform of RECK. Nimbolide suppresses the features of the molecules that inhibit the perform of RECK”13,14
Breast most cancers: The newest findings, revealed in August, 2018, have been carried out by scientists at The Nationwide Institute of Pharmaceutical Schooling and Analysis (NIPER) in India.
One of many scientific staff, Chandraiah Godugu, stated their research confirmed that nimbolide “considerably inhibited the expansion of breast most cancers and triple destructive breast most cancers cells…by novel molecular pathways. It induces cell dying and inhibits proliferation of most cancers cells.”
He additionally speculated that “nimbolide might even scale back the extreme unwanted side effects related to chemotherapeutic medicine. Because it exhibits anticancer exercise by attacking a number of pathways, the probabilities of drug resistance are very low.
“It might show useful towards relapsed tumor which poses the problem of drug resistance. It might even kill the dormant and resistant most cancers stem cells.”15
Shopping for neem
An incredible many neem merchandise can be found together with dietary supplements, toothpowder, toothpaste, mouthwash, pores and skin lotions, bodycare, cleaning soap, shampoo and conditioner. Neem timber and seedlings can be bought.
All merchandise can be found from Neem Tree Farms of Florida, the oldest and largest unbiased producer of neem timber and merchandise within the U.S. Nevertheless, neem merchandise are extensively out there elsewhere – even Walmart shares a variety of them.
WebMD describes neem as “probably protected” to take by mouth for as much as ten weeks, to use to the within of the mouth for as much as six weeks, and to use to the pores and skin for as much as two weeks. Longer purposes, they are saying, are “probably unsafe.” Briefly, not a lot is understood, and you may assume this web site is not any nice good friend of options.
Nimbolide – which appears to be an extract you’d need for most cancers — can’t be bought by itself, however some dietary supplements include a small quantity. As a result of neem is a strong immune system booster it shouldn’t be utilized by individuals with auto-immune illnesses together with lupus, rheumatoid arthritis or a number of sclerosis, besides beneath medical supervision.